[10][11] Byard had official private visits or workouts with 12 teams that included the Miami Dolphins, Green Bay Packers, Cleveland Browns, Titans, and Los Angeles Rams.

[20] Throughout training camp, he competed with Rashad Johnson for the vacant starting free safety position left by the release of Michael Griffin.

[23] Byard made his NFL debut in the Titans' season-opener against the Minnesota Vikings and collected five solo tackles in a 25–16 loss.

On November 13, Byard received his first career start and recorded seven solo tackles and made his first NFL sack on Packers quarterback Aaron Rodgers during a 47–25 victory.

[26] Although Johnson returned from injury in Week 10, Byard remained the starting free safety for the last seven games of the season.

He finished his rookie season with a total of 58 combined tackles (44 solo), one sack, and four pass deflections in seven starts and 16 games.

[28] Byard entered training camp slated as the Titans' de facto free safety after they opted not to re-sign Rashad Johnson.

[29] On October 1, 2017, he collected a season-high nine combined tackles and made his first career interception off of Deshaun Watson, as the Titans lost 57–14 to the Houston Texans.

[32] The following week, Byard made four solo tackles, defended three passes, and intercepted Baltimore Ravens' quarterback Joe Flacco twice to help his team earn a 23–20 victory.

[33] He became the fifth player in NFL history to record five interceptions in a two-game span joining DeAngelo Hall (2010), Albert Lewis (1985), Willie Buchanon (1978), and Mike Haynes (1976).

[41][42] On January 6, 2018, Byard started in his first NFL playoff game and recorded five solo tackles during a 22–21 win at the Kansas City Chiefs in the AFC Wild Card Round.

[43] The following week, Byard made ten combined tackles (nine solo) in the Titans' 35–14 loss at the New England Patriots in the AFC Divisional Round.

[48] In a 28–14 Week 9 road victory over the Dallas Cowboys, Byard intercepted quarterback Dak Prescott in the end zone.

[51] On December 22, 2018, in a 25–16 Week 16 victory over the Washington Redskins, Byard made an important late-game interception by picking off Josh Johnson.

[55][56] During the season-opener against the Browns, Byard made an interception off Baker Mayfield and returned it 28 yards in the Titans' 43–13 road victory.

[58] In the next against the Denver Broncos, he recorded an interception off Joe Flacco that bounced off tight end Noah Fant's back in the 16–0 road loss.

[59] In the next game against the Los Angeles Chargers, he caught an 11-yard reception from punter Brett Kern on a fake punt in the 23–20 victory.

[62] In the Divisional Round of the playoffs against the Ravens, Byard intercepted an early pass from Lamar Jackson to help set the tone for the 28–12 victory.

[63] In Week 1 against the Broncos on Monday Night Football, Byard recorded a team high 9 tackles and forced a fumble on running back Melvin Gordon during the 16–14 win.

[65] He finished the 2020 season with 111 total tackles (79 solo), one interceptions, seven passes defended, and one forced fumble in 16 games and starts.