[4] In 2015, she took part of the inaugural season of the Australian Women's Big Bash League playing for the Melbourne Renegades.

[6][7] In September 2019, she was named in the Devnarain XI squad for the inaugural edition of the Women's T20 Super League in South Africa.

[12] In the inaugural season of the Women's Premier League in 2023, van Niekerk was bought by Royal Challengers Bangalore at the price of 30 Lakhs.

Bowling leg-spin, she made her debut at 16 years of age in March 2009, during the World Cup match against the West Indies at Newcastle.

[18] In January 2013, she became the first South African woman to take an international hat-trick, finishing with 5/28 in an ODI match against the West Indies.

[27] In February 2017, during the 2017 Women's Cricket World Cup Qualifier, she became the seventh player to reach 1,000 runs and take 100 wickets in WODIs.

[34] In October 2018, she was named as the captain of South Africa's squad for the 2018 ICC Women's World Twenty20 tournament in the West Indies.

[44] On 23 July 2020, van Niekerk was named in South Africa's 24-woman squad to begin training in Pretoria, ahead of their tour to England.