A right-handed batter and occasional wicket-keeper, du Preez made her debut for the South Africa national women's cricket team in January 2007, aged seventeen.

[5][6] In April 2022, du Preez announced her retirement from Test and ODI cricket, allowing her to focus on the shorter format of the game and spend more time with her family.

She has explained that at that time, women's cricket was still exclusively amateur in nature, with limited funding and not many female role models.

[12] In 2014, du Preez captained South Africa in her debut and only Test match, against India at the Srikantadatta Narasimha Raja Wadeyar Ground in Mysore.

Du Preez then scored 102 in her maiden Test innings, but her team's total of 234 was not enough to prevent India from enforcing the follow on.

[14] On 21 June 2016, she decided to step down as South Africa women's captain, after having led the team for almost 5 years (since 2011) in one Test, 46 ODIs and 50 T20Is.

[18] In October 2018, she was named in South Africa's squad for the 2018 ICC Women's World Twenty20 tournament in the West Indies.

[21][22] In September 2019, she was named in the Devnarain XI squad for the inaugural edition of the Women's T20 Super League in South Africa.

[26] On 23 July 2020, du Preez was named in South Africa's 24-woman squad to begin training in Pretoria, ahead of their tour to England.

[37] Du Preez was raised in a Christian household, and dedicated her life to Jesus while attending a youth seminar at the age of 10.