Much of Danger Doom's music has been filled with material from and endorsed by Adult Swim, a block of animated television shows airing on cable's Cartoon Network.
Master Shake, Frylock, Meatwad, Carl Brutananadilewski, Ignignokt, and Err from the Adult Swim television show Aqua Teen Hunger Force all make appearances on The Mouse and the Mask.
Both the song's title and its lines "Chew an MC like El Chupa Nibre/Digest a group and sell the poop on eBay" reference the show Futurama.
", are direct references on the shows from which they derive their names, "Perfect Hair Forever" and "Aqua Teen Hunger Force".
In 2017 Doom's Metalface Records reissued The Mouse and the Mask with the previously unreleased track, Mad Nice, featuring Black Thought of The Roots.