The books follow main character, Weetzie Bat and her friends and family members, who all live in Los Angeles.

The books include supernatural elements such as witches, genies, and ghosts, and has been described as magical realism or mythpunk.

[5] The theme of Missing Angel Juan is stated by Michael Cart: "love, in its infinite varieties, is both humankind's natural estate and heart-magic strong enough to redeem any loss".

[6] In Baby Be-Bop, the theme is finding love for oneself and the book is meant as "a safety net of words for readers longing to feel at home with themselves".

[8] In 2005, Block received the Margaret Edwards Award "for outstanding contributions to young adult readers", for the Weetzie Bat books.