After retiring from the NHL in 2015, Carcillo created a non-profit organization that assists former NHL-players who are suffering from post-concussion syndrome and mental health issues.

Carcillo is the founder and CEO of Wesana Health, a life sciences company that leverages psilocybin-based medicine to treat traumatic brain injuries.

Carcillo, however, tore the anterior cruciate ligament (ACL) in his left knee on the play, and underwent surgery four days later, costing him the rest of the season.

[12] On September 4, 2014, the Pittsburgh Penguins signed Carcillo to a professional tryout contract in order to attend their 2014 training camp.

On January 16, 2015, Carcillo injured Winnipeg Jets' forward Mathieu Perreault while delivering a cross-check from behind after the play had been stopped.

[15] Perreault left the game and the NHL's Department of Player Safety issued Carcillo a six-game suspension and a fine of $40,243.92 for the hit.

[22][23] After winning the Stanley Cup in 2015, Carcillo retired from playing professional hockey and established the 'Chapter 5 Foundation', which is dedicated to helping players who are struggling with post-concussion syndrome, anxiety, or depression.

[27][28] Carcillo's accusations were corroborated by several other former Sting teammates, who joined him in a class-action lawsuit against the Canadian Hockey League in 2020.