During his post-doc at Duke, he discovered that cells can respond and adapt to the mechanical properties of their environment.

[4] Since 1996, he has researched the fundamental properties of the transmission of nerve impulses in the brain and developed new nanoscale imaging techniques.

He discovered that receptors move in living neurons[5][6] and that these movements in and out synapses participate to synaptic plasticity,[7] a phenomenon thought to underlie learning and memory.

Choquet's current work involves attempting to understand the role of receptor movements in neurodegenerative diseases.

His recent research work has earned him the 2004 CEA Prize and the 2009 CNRS Silver Medal.