Raised in the Toronto suburb of Etobicoke, DeSanto made his acting debut at the age of 8 as the lead protagonist in Brown Bread Sandwiches (a.k.a.

La famiglia Buonanotte), a film about Italian immigrants in Toronto written and directed by Carlo Liconti.

Prior to his first screen role, DeSanto had been in a juice commercial with Canadian figure skating star Elizabeth Manley, and was an avid hockey player.

[3] DeSanto is best known for playing Tucker on Are You Afraid of the Dark?,[3] his 2004 role as Jason in Mean Girls,[3] The Assassin in The Boondock Saints II: All Saints Day,[4] Matt in The Adventures of Dudley the Dragon, the TV show The Magic School Bus in which he voices Carlos Ramon, and for voicing Ray on the Beyblade[3] series and voicing Blaine on Totally Spies!.

[3] DeSanto also provided the voice of Dave in Total Drama Pahkitew Island.