Major-General Daniel Denison (c. 1612 – September 20, 1682) was an English-born military officer and politician who spent the majority of his life in the Massachusetts Bay Colony.

He arrived in Roxbury with his parents in 1631, likely with the "apostle" Puritan Minister John Eliot, on the ship Lyon.

He moved to Ipswich in 1635 to take up leadership responsibilities in the defense of the colony, and to develop a career in governance.

During King Philip's War in 1675 he was the commander of the Massachusetts Militia but was unable to serve in the field due to illness.

He died in Ipswich on September 20, 1682, and is buried in the High Street Burial Ground in that town.