Located at 445 East 42nd Street in the Grand Boulevard community area of Chicago Illinois, the building was designated a National Historic Landmark in 1975.

[3] The Daniel Hale Williams House stands on the south side of 42nd Street on Chicago's South Side, about 1/2 block east of Martin Luther King Jr. Boulevard.

It is a modest 1+1⁄2-story wood-frame structure, with a roughly L-shaped plan covered by a gabled roof.

The house is not of particular architectural interest, and is estimated to have been built about 1905, when it was purchased by Daniel Hale Williams.

Under his leadership, it trained a generation of medical professionals to exacting standards, and is where he performed the above-described operation.