He played college football at Appalachian State and was selected by the San Francisco 49ers in the fifth round of the 2011 NFL draft.

In the game, he contributed on special teams, but the 49ers fell to the Baltimore Ravens by a score of 34–31.

[7] The move was precipitated by the 49ers' signing of free agent center Weston Richburg the day before.

Kilgore started the first four games of the 2018 season at center before suffering a torn triceps in Week 4.

[9] On March 12, 2020, the Dolphins declined the option on Kilgore's contract, making him an unrestricted free agent.