Daniel L. Kastner (born 1951)[1] is an American physician and researcher specialising in the genetics of autoinflammatory disorders.

In 1987 his was one of two teams which simultaneously discovered and published the genetic mutation which causes FMF, and since then he has worked on disorders including TRAPS and DADA2.

The chair of the Crafoord Prize committee, Olle Kämpe [sv], said in 2021:Dan Kastner is often called the father of autoinflammatory diseases, a title that he thoroughly deserves.

His discoveries have taught us a great deal about the immune system and its functions, contributing to effective treatments that reduce the symptoms of diseases from which patients previously suffered enormously, sometimes leading to premature death[4]Kastner was elected to the National Academy of Sciences in 2010[7] and to the National Academy of Medicine in 2012.

[8] In 2018 Kastner was named "Federal Employee of the Year" in the Samuel J. Heyman Service to America Medals ("the Sammies").