[4] Daniel was a first cousin of the early advocate of women's equality Judith Sargent Murray and her brother, Gov.
[9] Like most of the successful merchants of his time, Daniel Sargent was a Federalist and a strong and active opponent of Jefferson's Embargo.
In 1798, he was chosen the first Captain of the then newly organized Boston Light Infantry, an office which he filled for five years.
Hepzibah was the daughter of Henry Atkins, also a distinguished Boston merchant, and the widow of James Brown, whom she married in 1788, but who died shortly thereafter.
[14] Daniel was a successful merchant in Boston retiring to Venice and buying the Palazzi Barbaro[15][16] Palazzo Barbaro became the hub of American life in Venice with visits from John Singer Sargent, Henry James, Whistler, Robert Browning and Claude Monet.
Other members of the “Barbaro Circle” included Bernard Berenson, William Merritt Chase, Isabella Stewart Gardner, and Edith Wharton.