Daniel Sargent Sr. (March 18, 1730 – February 18, 1806) was an American merchant in Gloucester, Massachusetts, and then Boston.

[4] His father was one of the largest landholders in Gloucester and had is portrait painted in 1760 by John Singleton Copley two years before his death in 1762.

[8] John Singleton Copley portrait of Mary Turner Sargent is at Fine Arts Museums of San Francisco.

[3] Through his second son Ignatius, he was the great-grandfather of Harvard botanist Charles Sprague Sargent (1841–1927).

[3] He was also the four-times-great grandfather of John Turner Sargent, CEO of Macmillan Publishers.