Daniele Gaither was born in Saint Paul, Minnesota and graduated from Northwestern University.
Gaither appeared in an episode of MADtv's second season, which featured rap star Ice-T.
The skit depicted a mock debate between U.S. President Bill Clinton (played by Bryan Callen) and U.S.
Senator Bob Dole (played by David Herman) who transformed himself into a "twisted" version of the 1970s blaxploitation icon Dolemite.
Gaither officially joined the cast of MADtv in 2003 as a featured performer for the ninth season.