Mike Tyson Mysteries is an American adult animated television series, and is the first collaboration between Warner Bros.

It premiered on October 27, 2014 on Cartoon Network's nighttime programming block Adult Swim.

During a May 2020 interview, writer Larry Dorf revealed the show had not been renewed and the fourth season would be its last.

The show's first season currently holds an 82% approval rating on Rotten Tomatoes based on 11 reviews, with an average rating of 6.2/10, with the site's consensus reading: "A dizzying whirl of lowbrow and high-concept, Mike Tyson Mysteries should more than satisfy fans of Adult Swim's signature blend of animated silliness.

[11] In a May 2020 podcast interview, writer Larry Dorf confirmed that the fourth season would be its last, although Davidson, Ramras, and Dorf would continue working together on a new project for Warner Bros.[6][7] In Canada, Mike Tyson Mysteries was exclusively available on Netflix until June 30, 2022.