In 2007, she was cast in the 2009 drama film Wild About Harry (originally titled American Primitive) playing the part of Madeline, a 1970s teenager who comes to realize that her father is gay.

[7] Savre has made guest appearances in several television shows like The X-Files, CSI: Crime Scene Investigation and Charmed.

[citation needed] She had recurring roles in the television show Summerland as Callie, and the NBC series Heroes as Jackie Wilcox.

[10] In 2018, Savre was cast as a main character, the bisexual firefighter Maya Bishop, on the Grey's Anatomy spinoff drama series Station 19.

[14] In 2021, Savre donated her eggs to her childhood friend Chris Ogden-Harkins so he could start a family with his husband, she is in a relationship with Kevin McKidd, who stars on Station 19's parent show Grey's Anatomy.