He was part of the Palmeiras teams who won the Libertadores consecutively in 2020 and 2021, solidifying himself as a stalwart in the middle of the park and becoming a consistent first-team starter.

[4] He made his senior debut for Cajazeiras on 5 May 2018, aged 17, by coming on as a second-half substitute in a 4–0 Campeonato Baiano Segunda Divisão home routing of Conquista [pt].

[7] He scored his first professional goal on 2 December, netting his team's fifth in a 5–0 Copa Libertadores home routing of Delfín SC.

In January 2023, Danilo joined Premier League side Nottingham Forest for an estimated £16 million fee, signing a six-and a-half-year deal with the English club in the process.

[8][9] On the opening day of the 2024–25 season against Bournemouth, he suffered a leg injury in the 8th minute, which could see him miss the entirety of the campaign.