Born in São Paulo, Murillo lost his father, a lifelong supporter of Corinthians and the person who led him into playing futsal, at the age of 10.

[2] On 16 January 2023, after playing for the under-20 side in the year's Copa São Paulo de Futebol Júnior, he was promoted to the first team.

[4] He made his first team debut on 26 April, coming on as a second-half substitute for Bruno Méndez in a 2–0 home win over Remo, for the year's Copa do Brasil.

[6] He quickly became a regular starter under head coach Vanderlei Luxemburgo during the season, attracting interest of several European clubs, such as Napoli, Manchester City and West Ham United.

[7] On 31 August 2023, Murillo signed with Premier League side Nottingham Forest on a five-year deal for an undisclosed fee.