He made his debut for the club against General Díaz in the league first division on 11 August 2014.
[3] He has made 88 league appearances in total, scoring 10 goals with the club.
He made his debut for the club on 18 July 2018, playing full 90-minutes in a 1–2 home loss against Olimpia.
On 2 August 2023 he scored his first goal with Deportivo Pereira against IDV in 2023 Copa Libertadores the match finish with a result 1-0.
Santacruz was summoned for Paraguay national under-20 team to play 2015 South American Youth Football Championship.