He was promoted to the first team in the summer of 2008[citation needed] and made his debut for Fortuna on 15 August 2008, appearing as a substitute in an away match against Go Ahead Eagles.

[9] Four days later on 21 November 2012, he made his second UEFA Champions League appearance, in the group stage match at home against Borussia Dortmund, coming on as a substitute in the 63rd minute for Eyong Enoh.

The match ended in a 1–4 loss for the Amsterdam side, with Danny Hoesen scoring the only goal, off of an assist from his teammate Christian Eriksen.

On 30 January 2014, it was announced that Danny Hoesen would serve out the remainder of the 2013/14 season on a 6-month loan deal playing for Thessaloniki club PAOK FC in the Superleague, where he worked with Dutch coach Huub Stevens.

[12] On 2 February 2017, it was announced that Hoesen was acquired on a season-long loan by Major League Soccer side San Jose Earthquakes with an option to buy.

[15] He earned MLS Team of the Week honours after again tallying a goal and an assist in the same game, this time in a 2–1 victory over Real Salt Lake on 24 June.

[16] Hoesen scored the game-winner off the bench in the knockout round of the 2017 Lamar Hunt U.S. Open Cup against Seattle Sounders FC on 28 June, recording his first cup goal for the club and giving San Jose its first-ever USOC victory over an MLS side, in addition to advancing San Jose to the quarterfinals for the first time since 2012.

[17] In an interview with Dutch website FC Update on 7 July, Hoesen stated that he hoped to stay at San Jose permanently.

[22] After just five appearances with the club, Austin FC head coach Josh Wolff announced that Hoesen would miss the rest of the 2021 season due to a hip injury which required surgery.