McGuire was awarded the Harry Sunderland Trophy in two Grand Finals, one of only three men to do so, alongside his former team-mates Kevin Sinfield and Rob Burrow.

McGuire was also the first player to score 200 tries in the Super League and he became the highest try-scorer in the competition's history in 2012, surpassing his former team-mate, Keith Senior.

McGuire impressed for the academy side and made his début for the Leeds Rhinos' first-grade team at Headingley Stadium, against the Salford City Reds on 6 July 2001.

McGuire's superb form resulted in him being awarded the RLWBA Player of the Year, to also add him being named in the 2004 Super League Dream Team.

As Super League IX Champions, the Leeds Rhinos faced 2004 NRL season Premiers, the Canterbury-Bankstown Bulldogs in the 2005 World Club Challenge.

He was part of the Leeds Rhinos' 2008 World Club Challenge winning squad, defeating the 2007 NRL Season Premiers, the Melbourne Storm, recording a final score of 11–4.

[12][13] McGuire's season ended in controversy though, during the Leeds Rhinos' win in their first play-off match against the eventual champions the Wigan Warriors.

Former Wigan Warriors star Phil Clarke, caused further controversy by writing, "Perhaps the rugby Gods have punished him (McGuire), for his unsportsmanlike play."

McGuire played at stand-off for the Leeds Rhinos in the 2011 Challenge Cup Final defeat by the Wigan Warriors at Wembley Stadium.

[21] The Leeds Rhinos won the 2015 Challenge Cup Final with victory over Hull Kingston Rovers at Wembley Stadium[22][23][24] and the 2015 League Leaders' Shield.

The Leeds Rhinos also claimed the spoils in the 2015 Super League Grand Final, in a thrilling encounter against the Wigan Warriors, eventually winning the game 20–22, which wrapped-up the domestic treble for the club at Old Trafford.

Danny recorded his first hat-trick of tries for Hull Kingston Rovers in a 52-22 Super League victory over the Salford Red Devils, on 8 July 2018 at Craven Park.

In pre-season ahead of the start of the 2019's Super League XXIV, Danny announced that the 2019 campaign would be his last as a player as he revealed his intentions to retire at the end of that same year.

[citation needed] On 20 May 2019, it was revealed that, following McGuire's retirement as a player, he would take on the role of Head of Recruitment at Hull Kingston Rovers from 2020's Super League XXV.