[citation needed] Radford played for the Bradford Bulls from the interchange bench in their 2003 Super League Grand Final victory against the Wigan Warriors.

Having won Super League VIII, Bradford played against 2003 NRL Premiers, the Penrith Panthers in the 2004 World Club Challenge.

Radford played for the Bradford Bulls at loose forward in their 2005 Super League Grand Final victory against the Leeds Rhinos.

[citation needed] Radford later returned to his hometown club of Hull FC, who he joined for the start of 2006's Super League XI.

Lee Radford took part in a boxing match, the Rumble in the Humber, against fellow rugby league player, Stuart Fielden which raised £50,000 for Steve Prescott.

[12][13] That year he would also lead his team to the Super League play-off semi-finals but would fail to reach the final after being defeated by the Wigan Warriors 28-18.

In June 2020, it was announced that Radford had joined Major League Rugby side Dallas Jackals as defensive coach.

[16] On 6 March 2023, it was announced that Radford had left Castleford, by mutual agreement, with assistant coach Andy Last taking over as interim manager.