Santiago had a strong amateur career, including the following highlights:[1] In 1997, Danny made his professional debut with a first round knockout of Michael Watkins.
Between 1997 and 2002, Danny built a record of 22-0 and earned a shot at the WBA Fedelatin Light Heavyweight Title, where he suffered his first loss against Rocky Torres.
By 2004, Danny defeated the highly ranked Elvir Muriqi in Madison Square Gardens with a devastating first round knockout.
Santiago owned and operated a successful boxing gym which served as a popular training ground world champions, including Tavoris Cloud, Ricardo Mayorga, and Jermain Taylor.
He is the trainer for former WBC fecabox champion and current WBA N.A.B.A title holder Alexander Castro.