The Coliseum is named after baseball hall of famer Roberto Clemente, who died in a plane crash off Isla Verde International Airport in Carolina in 1972, while flying with relief articles to be given to victims of the Nicaragua earthquake.

The coliseum has been host to a variety of events, including world championship boxing and basketball, business expos, circus, concerts and other things.

Concerts that have been held there include: Van Halen were scheduled to perform during their III Tour on September 20 and December 11, 1998, but the shows were cancelled.

Most of the world championship boxing bouts fought in Puerto Rico during the late 1970s and early 1980s were fought at the Roberto Clemente coliseum, including Roberto Durán's world title defense versus Mexican Leoncio Ortiz, Wilfredo Gómez's knockout win against Carlos Zarate, many of Samuel Serrano's title defenses, and the fight where Muhammad Ali defended his title against Jean Pierre Coopman, the only time a world Heavyweight championship fight has been held in Puerto Rico.

[3] The Coliseum has also been the place of large political rallies, and Puerto Rico's electoral commission uses its facilities to count votes after each election, and also hosted Miss Universe 2002, won by Oxana Fedorova of Russia.