Daphne Koller (Hebrew: דפנה קולר; born August 27, 1968) is an Israeli-American computer scientist.

She was elected a member of the National Academy of Engineering in 2011 for contributions to representation, inference, and learning in probabilistic models with applications to robotics, vision, and biology.

[15] She and Andrew Ng, a fellow Stanford computer science professor in the AI lab, founded Coursera in 2012.

[19] Along with Suchi Saria and Anna Penn of Stanford University, Koller developed PhysiScore, which uses various data elements to predict whether premature babies are likely to have health issues.

[21] Koller is a leading figure in research that expanded the existing Bayesian-related software so that it is capable of discerning patterns in vast collections of data.

[24] Her former doctoral students include Lise Getoor,[2] Mehran Sahami,[2] Suchi Saria,[3] Eran Segal,[2] and Ben Taskar.