[1] He started his career in 1997, as member of the rap group Sacre Scuole, with Gué Pequeno and Jake La Furia.

In 2001, after releasing their first album (3 MC's al cubo), the group disbanded due to quarrels between him and Jake La Furia.

[2] After the experience with Sacre Scuole, Dargen D'Amico went on a solo career by releasing in 2006 the debut album Musica senza musicisti, published by Giada Mesi, an independent record label he founded.

He mentions Franco Battiato, Enzo Jannacci and Lucio Dalla as his biggest influences.

[3] D'Amico participated in the Sanremo Music Festival 2022[4] with "Dove si balla".