During the following years, she released the albums di20 (2015) and 2640 (2018), and several hit singles, including "L'amore esiste" (2015), "Nessun grado di separazione" (2016), "Vulcano" (2018), "Io non abito al mare" (2018) and (2019).

In 2020 Michielin published her fourth studio album Feat (stato di natura) with the lead single "Cheyenne", followed by Cani sciolti in 2023.

[3] During her career, Michielin competed twice in the Sanremo Music Festival, placing second both in 2016 with "Nessun grado di separazione" and in 2021 with "Chiamami per nome", performed with Fedez.

Michielin also co-wrote and produced songs with several Italian artists, including Måneskin, Giorgia, Elisa, Fabri Fibra, Carl Brave, Coma Cose, Emma Marrone and Gaia Gozzi.

In 2022 Michielin debuted as a novelist with the book Il cuore è un organo and hosted the docu-series Effetto serra and the new seasons of X Factor.

[9] Thanks to her brother, she developed an interest in rock music, and she later focused on artists like Bon Iver, Jeff Buckley and Damien Rice.

On 17 February 2012, Michielin appeared as a guest during the fourth night of the 62nd Sanremo Music Festival, performing the song "Al posto del mondo" with contestant Chiara Civello.

The single preceded her debut studio album, Riflessi di me, featuring collaborations with producer Andrea Rigonat and singer-songwriters Elisa and Roberto Casalino.

[34][35] In 2014, Michielin took part in the theatrical performance La ragazza con l'orecchino di perla, with music written by Franco Battiato.

[37] The song, entirely composed in English, was written by Michielin with Fausto Cogliati and Negin Djafari for the Italian version of the soundtrack of The Amazing Spider-Man 2.

[55] "Nessun grado di separazione" debuted atop the Italian singles chart and was included in di20are, a new edition of Michielin's second studio album.

[64] The album's lead single "Vulcano" was released on 21 July 2017,[65][66] along with a music video directed by Giacomo Triglia and filmed between 10 pm and 5:30 am in Berlin.

[74] In an interview with Rolling Stone, Michielin said that the song is a criticism of people who chase change and run away to exotic and remote places with the idea of living a more genuine life and making a difference, without realising that the problem to be solved is often within them.

[76] In May 2018, Michielin also provided featured vocals, together with rapper Fabri Fibra, on the single "Fotografia" by Italian recording artist Carl Brave.

[82][83][84] Titled Feat (stato di natura) and released on 13 March 2020, the album included 11 tracks, all of which featured other artists, with the main theme being the contrast and union between urban and natural environments.

A new song from the album was premiered during each event, and released on the following day—"Gange", featuring Italian rapper Shiva, was released after the performance which took place at the Rocket nightclub on 20 February 2020;[87] "Riserva naturale", featuring Coma Cose, premiered on 27 February 2020 during a show which was set to take place at the Serraglio nightclub, but was turned to a Facebook livestream session due to restrictions aimed at containing the outbreak of the COVID-19 pandemic in Italy.

[95][96] In the meanwhile, Michielin performed a cover of Gianni Morandi, Enrico Ruggeri & Umberto Tozzi's "Si può dare di più" with Levante and Maria Antonietta for the third night of the 70th Sanremo Music Festival, on 6 February 2020.

[97] She was among the artists involved in the charity event Musica che unisce, created as a collage of home made contributions and performances recorded and broadcast during the COVID-19 lockdown,[98] and she performed "Cheyenne" from a panoramic corner in her hometown Bassano del Grappa during the 2020 International Workers' Day concert, annually supported by Italian trade unions CGIL, CISL and UIL and adapted in 2020 to a televised show without any audience.

[99][100] On 22 January 2021, Michielin released the song "Cattive stelle" with Vasco Brondi, as an addition to her previous album Feat (stato di natura).

[101] In February of the same year, she launched her podcast titled Maschiacci – Per cosa lottano le donne oggi?, interviewing celebrities about topics related to the fight against gender stereotypes.

[106] Michielin also dueted with Samuel on the single "Cinema", and later recorded the song "Nei tuoi occhi" for the soundtrack of the film Marilyn's Eyes.

[107][108] Michielin was the orchestra conductor at the Sanremo Music Festival 2022 during Emma Marrone's performances of her entry "Ogni volta è così", and she dueted with her on a cover version of "...Baby One More Time".

[114] In March 2022, Michielin debuted as a record producer on the track "Liberi", included on the album Caos by Italian rapper Fabri Fibra.