After being founded and joining the Belgian FA on 28 June 1922 to start with matricule n°223, the club played under several names in the first few seasons.

In the Third Division, SC Louvain was paired with both city rivals, but finished dead last, relegating back to the provincial levels immediately.

This time however, SC Louvain was able to avoid relegation, already becoming fourth in 1936, the season in which Stade Leuven became champions.

For three seasons the club was reunited with Stade Leuven, now in the Fourth Division, before being relegated into the provincial leagues in 1967.

Towards the end of the 1990s, the club was going up and down between the first and second provincial level, finally spending its last season in the first provincial level in 2001–02, after which it dissolved as it merged with Stade Leuven and Zwarte Duivels Oud-Heverlee to form Oud-Heverlee Leuven.