The colonized planet Darius is recuperating from its invasion from the alien Belser Army thanks to that game's heroes Proco and Tiat.

The space flight Headquarters established on Olga picks up an SOS signal coming from Earth, where the first colonists originated before colonizing Darius.

Suspecting these might be their remaining Earthling ancestors, the people of Darius sends both Proco Jr. and Tiat Young to help them.

It is somewhat based on the Mega Drive port, and while Tiat Young and her abilities are still present (though even more limited), many zones (and thus bosses) have been completely removed.

This version features an entirely new set of bosses, major changes to levels, and a fully arranged soundtrack including new songs.

On October 5, 2023, it was released for the Nintendo Switch and PlayStation 4 by Hamster Corporation through the Arcade Archives lineup.

In Japan, Game Machine listed Darius II on their November 15, 1989, issue as being the sixth most-successful upright/cockpit arcade unit of the month.