Darlene Magnolia Ricasa Antonino-Custodio (born December 26, 1973) is a Filipina former politician who served as mayor of General Santos from 2010 to 2013 and as the Representative of South Cotabato's 1st district from 2001 to 2010.

She gained national attention in the 2007 elections when she defeated world boxing champion Manny Pacquiao in his first foray into politics.

She holds a master's degree in Culinary Arts in the prestigious school Le Cordon Bleu in London, England.

In November 2021, addressing speculations of a political comeback in the 2022 elections, Antonino Custodio announced that she was not running for mayor of General Santos.

Her father and mother, Adelbert and Luwalhati R. Antonino both served as mayor and house representative of General Santos and South Cotabato.