He led the Coyotes to their first California Interscholastic Federation (CIF) title after scoring five touchdowns on offense, defense and special teams in a 42–3 win over Palos Verdes.

[2] A five-star recruit,[1] he committed to the University of California, Los Angeles (UCLA) to play college football.

Holmes was selected by the New York Giants with the 110th pick in the fourth round of the 2020 NFL Draft.

[10] In Week 13 against the Seattle Seahawks, Holmes recorded his first career interception off a pass thrown by Russell Wilson during the 17–12 win.

[11] On November 30, 2021, Holmes was placed on the injured reserve list after suffering a rib injury after intercepting Eagles quarterback Jalen Hurts.