He was named second-team All-Mid American Conference (MAC) selection in his junior season after recording 111 tackles, including 10.5 for loss, three sack, three interceptions and two forced fumbles.

[2] As a senior, Spillane was again named second-team All-MAC after compiling 88 tackles, 11 of which were for loss, 1.5 sacks and an interception, which he returned 35 yards for a touchdown.

[5] He was cut from the 53-man roster at the end of training camp and subsequently re-signed to the Titans practice squad on September 2.

[15] On October 18, 2020, against the Cleveland Browns, Steelers starting inside linebacker Devin Bush Jr. tore his ACL.

[16] In Week 8 of the 2020 season, Spillane intercepted a pass from Baltimore Ravens' quarterback Lamar Jackson and returned it for a 33 yard touchdown during the 28–24 win.

[17] In Week 10 against the Cincinnati Bengals, Spillane recorded his first career sack on rookie quarterback Joe Burrow during the 36–10 win.

[28] Spillane is the grandson of 1953 Heisman Trophy winner, College Football Hall of Famer and NFL halfback Johnny Lattner.