His descendant in the fourth generation was Henry Stewart, Lord Darnley (1546–67), the second but eldest surviving son of Matthew Stewart, 4th Earl of Lennox, (the courtesy title "Lord Darnley", his father's subsidiary title, designating him as heir apparent to the Earldom of Lennox), and the husband of Mary Queen of Scots by whom he was the father of King James VI of Scotland, I of England.

[2] During the second half of the 20th century, Darnley experienced total transformation from being a modest semi-rural community[3][4] to becoming a significant part of Glasgow's response to a post-war housing shortage.

[5] This scheme was to occupy an area to the north of Nitshill Road covered by Leggatston Farm, part of the original Darnley estate taken within the City of Glasgow boundaries in 1938.

It was intended that Darnley would be a largely self-supporting estate and for this reason, two primary schools and a community centre formed part of the council's plans.

[14][15][16] A £20 million refit and extension programme of Sainsburys began in February 2010;[17][18] work included raising the store from 44,000sqft to 89,000sqft, constructing a mezzanine floor at the Nitshill Road side, a new petrol station and double-deck car parking area.

The new petrol station opened on 20 August 2010, the first in the company to have green-energy solutions such as solar energy panels and rain-water recycling for its car wash.