As an ordained Presbyterian minister, he served as a student outreach pastor and as a faculty member of the Karlshohe College in the German Lutheran Church.
His writing and teaching focus on the theology of the missional church, especially the theological implications of the paradigm shift to post-Christendom as the context for Christian mission in the West.
Darrell Guder also serves as Senior Fellow in Residence at The Centre for Missional Leadership at St. Andrew's Hall on the campus of The University of British Columbia, Canada.
His scholarly translations include Otto Weber, Foundations of Dogmatics (2 vols.
); Eberhard Jüngel, God as the Mystery of the World; Karl Barth, The Theology of the Reformed Confessions (with Judith Guder; Eberhard Busch), and The Great Passion: An Introduction to the Theology of Karl Barth (with Judith Guder).