Darren Lee Holmes (born April 25, 1966) is an American former professional baseball pitcher.

Holmes played in Major League Baseball (MLB) from 1990 to 2003 for the Los Angeles Dodgers, Milwaukee Brewers, Colorado Rockies, New York Yankees, Arizona Diamondbacks, St. Louis Cardinals, Baltimore Orioles, and Atlanta Braves.

He was selected in the 16th round of the 1984 MLB Draft by the Los Angeles Dodgers and opted to turn professional and forgo his scholarship at UNC.

[1] When play resumed in 1995, he had a revival, going 6–1 with an ERA of 3.24 and helping the Rockies reach the playoffs.

[1] Despite not earning a win in the regular season, and picking up two saves, he appeared on the Yankees postseason roster and earned a World Series ring when the Yankees swept the Padres in 1998.

Holmes was traded to the Diamondbacks on March 3, 1999, for Ben Ford and Izzy Molina.

He also threw 2+2⁄3 innings in the 2002 National League Division Series, allowing one hit while striking out five.

[2] On December 23, 2019, Holmes was named the bullpen coach of the Baltimore Orioles.

[4] On December 20, 2023, Holmes was hired by the Chicago Cubs to serve as the team's bullpen coach.