He played college football for the Georgia Tech Yellow Jackets and was selected by the Baltimore Ravens in the sixth round of the 2015 NFL draft.

[5] Waller attended and played college football at Georgia Tech as a wide receiver where he redshirted his freshman season of 2011 and decided to forgo his final year of eligibility by entering the 2015 NFL draft.

[11] Throughout training camp, Waller competed for a roster spot as a backup wide receiver against Marlon Brown, Michael Campanaro, and Kamar Aiken.

[12] Head coach John Harbaugh named Waller the sixth wide receiver on the depth chart to begin his rookie season, behind Steve Smith Sr., Aiken, Campanaro, Brown, and Breshad Perriman.

[14] In March, it was announced by head coach John Harbaugh during a news conference that Waller would be converting to the tight end position.

[15] On July 1, 2016, Waller was suspended for the first four games of the 2016 NFL season for violating the league's substance-abuse policy.

[17] On August 7, 2018, Waller was reinstated by the league after completing a rehabilitation program at Borden Cottage and serving his year-long suspension.

[23] On Hard Knocks with the Raiders, he was featured in an episode detailing his struggle with substance abuse and his steps taken to overcome it.

[37] In Week 13 against the New York Jets, Waller had 13 receptions for 200 receiving yards, establishing a new Raiders franchise record for a tight end, while also scoring two touchdowns in a 31–28 win.

[46] In the 2021 regular season opener, Waller had ten receptions for 105 receiving yards and a touchdown in the 33–27 overtime victory over the Ravens.

[50] On September 10, 2022, Waller signed a three-year, $51 million contract extension with the Raiders, becoming the highest-paid tight end in the league.

[58][59] After spending 34 days in a substance abuse rehabilitation program in Camden, Maine, he took a job stocking shelves at a Sprouts Farmers Market.

"[60] On March 4, 2023, Waller married Las Vegas Aces point guard Kelsey Plum.