It covers original scientific research, multidisciplinary review articles, and science news.

[5] The journal was started in 1998 by Tim Lesle, Soon Hyouk Lee, Arvindh Kanagasundram, and Amar Dhand and established with the publication of the first issue in the Spring of 1999.

[6][7][8] The journal expanded its impact on campus over the next few years[citation needed] and launched its website, DUJS Online, to feature more frequent science news articles covering events at Dartmouth and select publications by Dartmouth faculty.

In 2012, the journal further expanded its outreach through a partnership with the Undergraduate Office of Admissions and hosted an International Science Essay Competition for high school students.

In 2020, the journal created another annual international high school competition called Building the Modern MD with the aim of giving students interested in studying pre-medical studies in college a platform to explore the intersection of humanities and medical science.