[2] The facility is best known for its 2,509-seat multi-purpose arena that is home to multiple Drexel University Dragons sports teams including basketball and wrestling.

When originally opened in 1975 as the Physical Education Center, sometimes just referred to as the "New Gym", the facility included grandstands that sat a capacity of 1,800, and was expandable to 2,700 seats with temporary bleachers.

[5] At the 2006 convocation Drexel University president Constantine Papadakis announced a 60,000-square-foot (5,600 m2), three-story addition to the existing Daskalakis Athletic Center.

In 2013, the DAC hosted four games of the 2013 Women's NIT, with the Dragons defeating Utah 46-43 in the final to win the tournament.

The DAC was built in 1974 as the Physical Education and Athletic Center (PEAC)[9] and was renamed in 2001 after a gift from former Drexel Lacrosse player John A. Daskalakis ('63).

Previously, the annual event was held in other areas including the Drexel Academic Quad, and Buckley Green.

The headlining acts of the Spring Jam concerts performed at the Daskalakis Athletic Center have included: Previous to the Drexel Campus Activities Board hosting the Spring Jam, their annual concert was in the Fall From 2011 through 2019, the annual US Open of Squash was held in the arena.

[19] The DAC hosted the World Team Tennis Championship match between the Philadelphia Freedoms and Springfield Lasers on August, 5th 2018.