It hosted the 2000 and 2001 title games of the America East Conference men's basketball tournaments, and also hosted two Postseason NIT games in 2006 (against Nebraska of the Big Twelve, and Old Dominion of the CAA).

In 2006, Hofstra Arena was renamed the 'David S. Mack Sports and Exhibition Complex'.

Before an overtime loss to Drexel University in February, the Pride had previously won 28 consecutive regular season home games at the Mack.

Mack Sports Complex also hosts other events year round, such as college fairs, graduations and Kellenberg Memorial High School's Blue and Gold Sports Night.

On September 26, 2016, it hosted the first presidential debate of the 2016 election between Republican Donald Trump and Democrat Hillary Clinton.