Daugavpils county (Latvian: Daugavpils apriņķis) was a historic county in the Vitebsk Governorate, and in the Republic of Latvia dissolved during the administrative territorial reform of the Latvian SSR in 1949.

Established in 1621 as one of the subdivisions of the Inflanty Voivodeship (powiat dyneburski) of the Polish–Lithuanian Commonwealth.

After signing of the Latvian–Soviet Peace Treaty, Daugavpils county was fully incorporated into the Republic of Latvia.

At the time of the Russian Empire Census of 1897, Dvinsky Uyezd had a population of 237,023.

Of these, 39.0% spoke Latvian, 20.0% Yiddish, 15.3% Russian, 13.8% Belarusian, 9.1% Polish, 1.8% German, 0.4% Lithuanian, 0.2% Tatar, 0.1% Romani and 0.1% Ukrainian as their native language.