Brandon took over Domino's in March 1999 when founder Tom Monaghan sold it to the investment group Bain Capital.

While in Ann Arbor, he was a back-up defensive end on the university's football team, under the leadership of Bo Schembechler.

Brandon described moving from Procter & Gamble to Valassis, then a small, family-owned coupon company, as a "culture shock.

[16] Under Brandon's direction, Domino's introduced the first pizza tracker,[17] and added desserts[18] and sub sandwiches[19] to its menu.

To promote the new products, Brandon appeared on a national TV commercial to burn a cease-and-desist letter from Subway.

[25] On May 5, 2005, Brandon appeared on the third edition of Donald Trump's The Apprentice as part of the finale CEO interview panel.

[26] In an advertisement that first aired on January 21, 2009, David starred by "oven baking" a cease and desist order from Subway.

[29] University President Mary Sue Coleman said she chose Brandon because she believed his financial management experience would serve the department well as it grew larger and increasingly complex.

Within a few years, Brandon began returning surpluses in the hundreds of millions of dollars, which the university used for a number of major facilities improvements.

In a U.S Bankruptcy Court filing on March 15, 2018, the company determined that the best way to maximize their recoveries would be to liquidate the existing inventory.

[41] Brandon sits on the Board of Directors for Detroit Edison as the Finance, Organization & Compensation and Public Policy and Responsibility Committees.