[7][15] He spent two years at the National Institutes of Health as a Howard Hughes Medical Institute-NIH Research Scholar.

[19] At the Memorial Sloan-Kettering Cancer Center in New York, he was an attending physician in the Department of Medical Oncology and head of the Laboratory of Tumor Biology.

The center grew out of earlier clinical projects at Cedars-Sinai, where Agus served as an attending physician in oncology, which observed striking differences between the aggressiveness of prostate cancer in certain patients and their ability to respond to treatment.

The group launched the OneShot campaign in October 2022 to build global digital health infrastructure and promote life course disease prevention programs.

[44] He has hosted public health conversations with individuals like Bill Clinton,[45] Joe Biden,[46] and Albert Bourla, CEO of Pfizer.

[49][9] His books A Short Guide to a Long Life[10] and The Lucky Years: How to Thrive in the Brave New World of Health[50] are also New York Times and international bestsellers.

[53] Loberg issued a public apology and Agus stated that she misled him during the writing process by claiming to use antiplagiarism software.

[54] Agus reviewed earlier works co-written by Loberg and informed Simon & Schuster that she had previously engaged in plagiarism.

[55] Other publishers and physicians who had worked with Loberg, including Penguin Random House, Sanjay Gupta, and David Perlmutter, subsequently discovered further plagiarism by her.

In the show, Agus discussed different medical issues with celebrity guests who have experience with those health concerns.

[67] Agus and Mark Sliwkowski published the first studies with an antibody called 2C4 (pertuzumab or Perjeta), targeting the Her-2 molecule in breast and other cancers.