David Baker (born October 6, 1962) is an American biochemist and computational biologist who has pioneered methods to design proteins and predict their three-dimensional structures.

He then joined the laboratory of Randy Schekman, where he worked primarily on protein transport and trafficking in yeast, and obtained a Doctor of Philosophy in biochemistry from the University of California, Berkeley in 1989.

Although primarily known for the development of computational methods for predicting and designing the structures and functions of proteins, Baker maintains an active experimental biochemistry group.

[16][17][18] Baker served as the director of the Rosetta Commons, a consortium of labs and researchers that develop biomolecular structure prediction and design software.

Baker's group has regularly competed in the CASP structure prediction competition, specializing in ab initio methods, including both manually assisted and automated variants of the Rosetta protocol.