She is Professor in the Department of Computer Science and the Lewis-Sigler Institute for Integrative Genomics at Princeton University and the Deputy Director for Genomics at the Flatiron Institute's Center for Computational Biology in New York City.

[6] She studies protein function and interactions in biological pathways by analyzing genomic data using computational tools.

[2][7][8][9][10][11][12] Troyanskaya completed her Bachelor of Science degree in Computer Science and Biology at the University of Richmond in 1999 and her Ph.D. Biomedical Informatics at Stanford University in 2003.

[1][3][13] In 2011, she was awarded the Overton Prize from the International Society for Computational Biology (ISCB).

[16] In 2020, she was elected Fellow of the Association for Computing Machinery (ACM) " for contributions to computational biology and data integration.