David Brydie Mitchell (October 22, 1766 – April 22, 1837) was a Scottish born American politician in Georgia who was elected in 1809 as governor of the state, serving two terms.

Mitchell resigned from the governorship in 1817 to accept an appointment by President James Monroe as United States Indian Agent to the Creek Nation in their lands in present-day Georgia and Alabama.

Mitchell married Jane Mills in 1792, and according to family records the couple had six children: William, John, Sara, Edward, Mary, and David II.

He resigned from his third term as governor to accept appointment by President James Monroe as the U.S. agent to the Creek Indians.

While his direct responsibility remains controversial, Mitchell allowed those engaged in this illegal activity to seek refuge for their captives at the agency he supervised along the Flint River.