He is best known for playing Coop on Megas XLR and Jerry Russo on Wizards of Waverly Place.

He also had special appearances in Gilmore Girls season 4 episodes 20 and 21 as TJ's brother.

DeLuise is also known for voicing Coop on the short-lived action animated Megas XLR (later reprising his role for the Cartoon Network game FusionFall) and Sergeant Brutto in Roughnecks: Starship Troopers Chronicles.

In 2005, he starred opposite Maggie Wheeler on the NBC pilot The Sperm Donor.

He has since directed episodes of How to Rock, See Dad Run, Lab Rats, and The Thundermans.