In 1935, he graduated from the Tbilisi State Conservatory, studying under Professor Vronsky.
That year, the young baritone sang at the Tbilisi Opera and Ballet Theatre the role of Prince Yeletsky from Tchaikovsky's opera The Queen of Spades.
In 1937 in Moscow, Georgian Literature and the Arts of the decade, he performed Kiazo's role in Paliashvili's opera Daisi (Sunset).
In 1947 he took the role of the Commissar (Sergo Ordzhonikidze) in Vano Muradeli's ill-fated opera, The Great Friendship.
Gamrekeli's opera repertoire included thirty opera roles, including Tchaikovsky's Eugene Onegin, Verdi's Rigoletto, the roles of Renato and Germont, Escamillo from Bizet's Carmen and others.