[10] In 2012, he reached the quarterfinals of an ATP World Tour tournament for the first time at the 2012 Chennai Open, after defeating top-50 countryman Xavier Malisse and Andreas Beck.

At the French Open 2012, though he did not win in the last qualifying round of the qualifications, he entered the tournament's main draw as a lucky loser thanks to the withdrawal of Gaël Monfils.

Goffin then beat Łukasz Kubot in the third round to become the first lucky loser to reach the last 16 of a Grand Slam since compatriot Dick Norman at Wimbledon 1995.

Goffin had to retire in his second-round match at the Challenger event in New Caledonia, and he withdrew from qualifying for the Australian Open due to a left quadriceps injury.

From July to August, following his opening round loss at Wimbledon to defending champion Andy Murray, Goffin won four consecutive tournaments.

The first three were Challengers, but the fourth was his maiden ATP tour-level title when he won the Austrian Open Kitzbühel, beating Dominic Thiem in the final.

At the Swiss Indoors in Basel, he advanced to his first ATP 500 tournament final, beating Milos Raonic in the quarterfinals, his first win over a top-10 player.

[15] 2015 saw Goffin have continued success, reaching two more ATP finals and breaking into the world's top 20, as well as decent runs in the major tournaments.

Goffin reached the third round of the men's singles at the 2016 Olympics in Rio, beating Sam Groth and Dudi Sela before unexpectedly losing to Thomasz Bellucci.

He defeated Jo-Wilfried Tsonga in the quarterfinals and top seed Andy Murray in the semifinals, before losing to Rafael Nadal in the final.

Goffin reached the quarterfinals of a Grand Slam for the second time in Melbourne, following victories over Reilly Opelka, Radek Štěpánek, Ivo Karlović and Dominic Thiem.

In February, Goffin defeated defending champion Roberto Bautista Agut to reach the final of the Sofia Open.

[17] After losing in the Round of 16 at both Indian Wells and Miami, Goffin led the Belgian Davis Cup team to victory over Italy in the World Group quarterfinals by winning both of his singles rubbers against Andreas Seppi and Paolo Lorenzi.

He then led Belgium to another Davis Cup victory against Australia in the World Group semifinals with four-set wins in both his singles rubbers against Nick Kyrgios and John Millman.

1 Rafael Nadal and Dominic Thiem secured him the runner-up spot in the Pete Sampras Group, behind Grigor Dimitrov.

Goffin ended the year having won all six of the singles rubbers he played in 2017, against France, Italy in the quarterfinals, and Australia in the semifinals.

In Rotterdam, Goffin was forced to retire from his semifinal match against Dimitrov after a ball ricocheted off his racquet and hit him in the left eye.

[38] As the top seed at the first edition of the Great Ocean Road Open, he was defeated in the second round by rising star Carlos Alcaraz.

[52] Turning to the grass-court season, Goffin, the seventh seed at the Halle Open, retired in the first round against Corentin Moutet due to an ankle injury.

[58] Seeded eighth at the Sydney Classic, he retired during his quarterfinal match against Andy Murray due to a knee injury.

[60] Seeded eighth and defending champion at the Open Sud de France in Montpellier, Goffin lost in the second round to Adrian Mannarino.

[64] Representing Belgium in the Davis Cup tie against Finland, Goffin won both of his matches over Otto Virtanen and Emil Ruusuvuori.

[75] Getting past qualifying at the Madrid Open, he made it to the third round where he lost in a three-hour and nine-minute three-set match to third seed, world No.

[80] Goffin was forced to skip the beginning of the grass season due to a left leg injury he sustained after losing to Hurkacz at Roland Garros.

In the beginning of his clay court season he qualified at the 2024 Grand Prix Hassan II and defeated Arthur Rinderknech.

He partnered with countryman Zizou Bergs in doubles to reach the quarterfinals where they lost in a tight match to the eventual champions, the American pairing of Nathaniel Lammons and Jackson Withrow.

[92] Despite winning the 2024 Ilkley Trophy,[93] he did not receive a wildcard for the 2024 Wimbledon Championships but climbed close to 30 positions up back in the top 100.

[94][95] He entered the All England Club main draw as a lucky loser but was defeated in a five-set thriller by Tomáš Macháč, after he was leading 5-0 in the fifth set.

[98] In Shanghai, Goffin made a second deep run, defeating James Duckworth, 15th seed Lorenzo Musetti, Marcos Giron and world no.

His good form continued in Basel, where he reached again the quarterfinals, having entered the main draw as a lucky loser, with an upset over fifth seed Ugo Humbert.