He has written several works in the horror genre, including the network series The Terror (2018) and the film Bones and All (2022).
While still living in Ohio, Kajganich was hired to adapt Heinrich Boll's The Lost Honour of Katharina Blum for the screen, but the project fell through.
[2] He wrote the screenplay for True Story (2015), a crime-drama starring Jonah Hill and James Franco, based on the Michael Finkel book of the same name.
[6] In 2016,[2] Kajganich began co-writing a new adaptation of Stephen King's Pet Sematary, which was released in 2019.
On April 8, 2019, it was announced that Kajganich would adapt Camille DeAngelis's novel Bones & All for the screen.